Menopausal Symptoms Abstracts
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AUTHOR: Murkies AL; Lombard C; Strauss BJ; Wilcox G; Burger HG;
Morton MS
ADDRESS: Brighton Medical Clinic, Brighton, Vic., Australia.
TITLE: Dietary flour supplementation decreases post-menopausal hot
flushes: effect of soy and wheat.
SOURCE: Maturitas (MWN), 1995 Apr; 21 (3): 189-95
LANGUAGE: English
COUNTRY PUB.: IRELAND
ABSTRACT:
Plants contain compounds with oestrogen-like action called
phytoestrogens. Soy contains daidzin, a potent
phytoestrogen, and wheat flour contains less potent
enterolactones. We aimed to show in 58 postmenopausal women
(age 54, range 30-70 years) with at least 14 hot flushes per
week, that their daily diet supplemented with soy flour (n =
28) could reduce flushes compared with wheat flour (n = 30)
over 12 weeks when randomised and double blind. Hot flushes
significantly decreased in the soy and wheat flour groups
(40% and 25% reduction, respectively < 0.001 for both) with
a significant rapid response in the soy flour group in 6
weeks (P < 0.001) that continued. Menopausal symptom score
decreased significantly in both groups (P < 0.05). Urinary
daidzein excretion confirmed compliance. Vaginal cell
maturation, plasma lipids and urinary calcium remained
unchanged. Serum FSH decreased and urinary hydroxyproline
increased in the wheat flour group.
AUTHOR: Strauss L; Santti R; Saarinen N; Streng T; Joshi S; Makela S
ADDRESS: Institute of Biomedicine and Medicity Research Laboratory,
University of Turku, Finland.
TITLE: Dietary phytoestrogens and their role in hormonally
dependent disease.
SOURCE: Toxicol Lett (VXN), 1998 Dec 28; 102-103 349-54
LANGUAGE: English
COUNTRY PUB.: NETHERLANDS
ABSTRACT:
Epidemiological studies suggest that diets rich in
phytoestrogens (plant estrogens), particularly soy and
unrefined grain products, may be associated with low risk of
breast and prostate cancer. It has also been proposed that
dietary phytoestrogens could play a role in the prevention
of other estrogen-related conditions, namely cardiovascular
disease, menopausal symptoms and post-menopausal
osteoporosis. However, there is no direct evidence for the
beneficial effects of phytoestrogens in humans. All
information is based on consumption of phytoestrogen-rich
diets, and the causal relationship and the mechanisms of
phytoestrogen action in humans still remain to be
demonstrated. In addition, the possible adverse effects of
phytoestrogens have not been evaluated. It is plausible that
phytoestrogens, as any exogenous hormonally active agent,
might also cause adverse effects in the endocrine system,
i.e. act as endocrine disrupters.
AUTHOR: Nagata C; Takatsuka N; Inaba S; Kawakami N; Shimizu H
ADDRESS: Department of Public Health, Gifu University School of
Medicine, Japan.
TITLE: Association of diet and other lifestyle with onset of
menopause in Japanese women.
SOURCE: Maturitas (MWN), 1998 Jun 3; 29 (2): 105-13
LANGUAGE: English
COUNTRY PUB.: IRELAND
ABSTRACT:
OBJECTIVES: To evaluate the cross-sectional relationships of
dietary and other lifestyle variables to menopause. METHODS:
A total of 4186 female residents aged 45-55 in Takayama
City, Japan, responded to a self-administered questionnaire
(the response rate was 89.3%). Diet in the past year was
assessed by semiquantitative food frequency questionnaire.
Using the logistic regression model, associations between
study variables and menopausal status were estimated in
terms of odds ratio (OR). RESULTS: Nulliparity and lower
relative weight were significantly associated with menopause
after controlling for age (P < 0.05). The association of
smoking with menopause was marginally significant after
controlling for age (P = 0.06). Higher intakes of fat,
cholesterol, and coffee were inversely and significantly
associated with later menopause after controlling for age,
total energy, parity, menarche age, and relative weight (ORs
for the highest tertiles of fat, cholesterol and coffee
intakes were 0.78, 0.79, and 0.70, respectively, P < 0.05).
The highest tertiles of calcium and soy product intakes were
significantly associated with menopause after controlling
for the covariates (ORs = 1.25 and 1.42, respectively, P <
0.05), but postmenopausal women who had menopause at later
age showed higher calcium intake than those who had
menopause at early age. CONCLUSION: Dietary factors appear
to be associated with onset of menopause.
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